Mechanisms of wound healing clarified in zebrafish study

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Mechanisms of wound healing clarified in zebrafish study

A crucial component of wound healing in many animals, including humans, is the migration of nearby skin cells toward the center of the wound. How do these neighboring skin cells know which way to migrate? A new paper from scientists clarifies the role of calcium signaling in wound healing.

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Oct. 29, 2013 — A crucial component of wound healing in many animals, including humans, is the migration of nearby skin cells toward the center of the wound. These cells fill the wound in and help prevent infection while new skin cells regenerate.How do these neighboring skin cells know which way to migrate? What directional cues are they receiving from the wound site? A new paper by Mark Messerli and David Graham of the MBL’s Eugene Bell Center for Regenerative Biology and Tissue Engineering clarifies the role of calcium signaling in this medically significant communication between skin cells.Messerli and Graham conducted the study using zebrafish skin cells, which migrate much faster than human cells. “Fish have to heal quickly,” Messerli says. “They are surrounded by microbes and fungi in the water. They are constantly losing scales, which generates a wound. So the wound has to be healed in the epidermis first and then a new scale has to be built. Fish skin cells (keratinocytes) migrate five times faster at room temperature than mammalian cells do at 37 degrees C. …

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Mechanisms of wound healing clarified in zebrafish study

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Mechanisms of wound healing clarified in zebrafish study

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